South-east Asians have the greatest genetic predisposition to develop coronary artery disease amongst all ethnic groups in the world. Of this population, Indians are the most susceptible group. This genetic predisposition coupled with a change in our life styles has led to an explosion of coronary artery disease in India. An estimated 50 million Indians suffer from coronary artery disease. We claim to be vegetarians, but consume unimaginable amounts of fat as ghee and oils. Sedentary life styles, lack of exercise, smoking and use of tobacco in alternative forms like 'gutka', snuff and chewed tobacco abound in our society. The stress of modern-day life superimposed on all these underlying risk factors has made coronary artery disease reach epidemic proportions in our cities with prevalence rates of 80-120 per thousand population. This reflects in the ever growing numbers of heart attacks, angiographies, angioplasties and bypass surgeries being performed daily. On the one side the numbers are growing in the elder population. On the other, the disease is affecting us at a younger age, estimated to be a decade earlier than in the West. Physicians are treating more and more patients in their thirties or even twenties nowadays. The situation, unless checked, is likely to worsen. It is estimated that by 2015 AD, one third of all deaths in India will be due to cardio-vascular causes.